Mechanisms of caspase activation. Pub. Med. Abstract. The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which reside as latent precursors in most nucleated metazoan cells. A majority of studies on apoptosis are based on the assumption that caspase precursors are activated by cleavage, a common mechanism for most protease zymogen activations. Although this appears to be true for the executioner caspases, recent research points to a distinct activation mechanism for the initiator caspases that trigger the apoptotic pathways. This mechanism is proximity- induced dimerization without cleavage, and its elucidation has led to the revision of concepts of feedback regulation of apoptosis. The first step in caspase activation is transition of the latent zymogen to an active form. For the initiator caspases, this occurs through dimerization of monomeric. The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which reside as latent precursors in most nucleated metazoan cells. A major. Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apo. Extrinsic & Intrinsic Pathways of Caspase Activation. Caspases are a family of aspartate-specific, cysteine proteases that serve as the primary mediators of apoptosis. 1. Nat Immunol. 2013 Jun;14(6):543-53. doi: 10.1038/ni.2595. Epub 2013 May 5. Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to.
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